Importance of Salivary Biomarkers in the Detection of Oral Cancer (Review Article)

Authors

  • Mohamed Yasser Kharma Al Farabi Colleges, Jeddah, Saudi Arabia, Aleppo University-Faculty of Dentistry – Syria, Department Oral Maxillofacial Surgery
  • Ossama Alkhatib Department Oral Maxillofacial Surgery, Inst, Al Farabi Colleges, Jeddah, Saudi Arabia
  • Mohamad Sadek Alalwani Department Basic Science, Inst, Al Farabi Colleges, Jeddah, Saudi Arabia
  • Wjoud Albishi Al Farabi Colleges Department, Oral Maxillofacial Surgery, Intern Jeddah, Saudi Arabia
  • Shahd Alalwi Al Farabi Colleges Department, Oral maxillofacial Surgery, Intern Jeddah, Saudi Arabia

DOI:

https://doi.org/10.12974/2311-8695.2017.05.02.2

Keywords:

Oral squamous cell carcinoma (OSCC), proteomics, tumor biomarkers, salivary biomarkers.

Abstract

Aim: This article aims to provide a brief overview of various salivary biomarkers and their importance in early detection of oral cancer. Background: The tumor markers are playing an important role in cancer detection and management. The cancer biomarker is produced either by the tumor itself or by other tissues, and consider as molecular signature indicating the physiologic and pathologic changes in a particular tissue or cell during the development of cancer. The direct contact between the saliva and the oral cancer lesions makes the salivary biomarkers the best sensitive and specific test for primairy screening method in diagnosis, staging and follow-up of oral cancer. Materials and Methods: Studies were conducted by searching for reviews in salivary biomarkers of oral malignancy in the past 5 years in Google Scholar, Medline, and PubMed. The references were also crosschecked for the relation of salivary biomarkers and oral cancer. Articles were identified and subjected to qualitative and quantitative analyses. Review Results: More than 100 potential Oral squamous cell carcinoma (OSCC) salivary biomarkers have been reported in the literature. The proteomics analysis of saliva proteins is significance for early diagnosis of Oral squamous cell carcinoma (OSCC). Saliva contains reliable amounts of cells, mainly exfoliated from the oral cancer, which can provide early diagnosis and detection of oral malignancy. Conclusion: The goal of cancer screening is to detect tumor at an early stage, when treatment is most likely to be successful. Salivary biomarkers will help to differentiate patients who clinically have no detectable disease but are potential candidates for oral cancer. 

References

Ram S and Siar CH. Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions. Int J Oral and Maxillofac Surg 2005; 34(5): 521-527. https://doi.org/10.1016/j.ijom.2004.10.008

Cheng YSL, Rees T and Wright J. A review of research on salivary biomarkers for oral cancer detection. Clinical and Translational Medicine (2014); 3: 1326-33. https://doi.org/10.1186/2001-1326-3-3

Wong DT. Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J Am Dent Assoc 2006; 137(3): 313-21. https://doi.org/10.14219/jada.archive.2006.0180

Castagnola M, Picciotti PM, Messana I, Fanali C, Fiorita A, et al. Potential applications of human saliva as diagnostic fluid. Acta Otorhinolaryngol Ital 2011; 31(6): 347-57.

Malamud, Daniel and Isaac R. Rodriguez-Chavez. Saliva as a Diagnostic Fluid. Dental clinics of North America 2011; 55.1: 159-178. https://doi.org/10.1016/j.cden.2010.08.004

Shpitzer T, Bahar G, Feinmesser R and Nagler RM. A comprehensive salivary analysis for oral cancer diagnosis. J Cancer Res Clin Oncol 2007; 133(9): 613-7. https://doi.org/10.1007/s00432-007-0207-z

Mizukawa N, Sugiyama K, Fukunaga J, Ueno T, Mishima K, et al. Defensin-1, a peptide detected in the saliva of oral squamous cell carcinoma patients. Anticancer Res 1998; 18(6B): 4645-9.

Chen YC, Li TY and Tsai MF. Analysis of the saliva from patients with oral cancer by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2002; 16(5): 364-9. https://doi.org/10.1002/rcm.588

Pickering V, Jordan RC and Schmidt BL. Elevated salivary endothelin levels in oral cancer patients–a pilot study. Oral Oncol 2007; 43(1): 37- 41. https://doi.org/10.1016/j.oraloncology.2005.12.027

St John MA, Li Y, Zhou X, Denny P, Ho CM, et al. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2004; 130(8): 929-35. https://doi.org/10.1001/archotol.130.8.929

Rhodus NL, Ho V, Miller CS, Myers S and Ondrey F. NFkappa B dependent cytokine levels in saliva of patients with oral preneoplastic lesions and oral squamous cell carcinoma. Cancer Detect Prev 2005; 29(1): 42-5. https://doi.org/10.1016/j.cdp.2004.10.003

Nagler R, Bahar G, Shpitzer T and Feinmesser R. Concomitant analysis o f salivary tumor markers–a new diagnostic tool for oral cancer. Clin Cancer Res 2006; 12(13): 3979-84. https://doi.org/10.1158/1078-0432.CCR-05-2412

Vucicevic Boras V, Cikes N, Lukac J, Virag M and Cekic- Arambasin A. Salivary and serum interleukin 6 and basic fibroblast growth factor levels in patients with oral squamous cell carcinoma. Minerva Stomatol 2005; 54(10): 569-73.

Hu S, Arellano M, Boontheung P, Wang J, Zhou H, et al. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res 2008; 14(19): 6246-52. https://doi.org/10.1158/1078-0432.CCR-07-5037

Katakura A, Kamiyama I, Takano N, Shibahara T, Muramatsu T, et al. Comparison of salivary cytokine levels in oral cancer patients and healthy subjects. Bull Tokyo Dent Coll 2007; 48(4): 199-203. https://doi.org/10.2209/tdcpublication.48.199

Jou YJ, Lin CD, Lai CH, Chen CH, Kao JY,et al. Proteomic identification of salivary transferrin as a biomarker for early detection of oral cancer. Anal Chim Acta 2010; 681(1-2): 41-8. https://doi.org/10.1016/j.aca.2010.09.030

Franzmann EJ, Reategui EP, Pedroso F, Pernas FG, Karakullukcu BM, et al. Soluble CD44 is a potential marker for the early detection of head and neck cancer. Cancer Epidemiol Biomarkers Prev 2007; 16(7): 1348-55. https://doi.org/10.1158/1055-9965.EPI-06-0011

Shpitzer T, Hamzany Y, Bahar G, Feinmesser R, Savulescu D, et al. Salivary analysis of oral cancer biomarkers. Br J Cancer 2009; 101(7): 1194-8. https://doi.org/10.1038/sj.bjc.6605290

He H, Chen G, Zhou L and Liu Y. A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland. J Cancer Res Clin Oncol 2009; 135(10): 1315-21. https://doi.org/10.1007/s00432-009-0572-x

Shpitzer T, Bahar G, Feinmesser R and Nagler RM. A comprehensive salivary analysis for oral cancer diagnosis. J Cancer Res Clin Oncol 2007; 133(9): 613-7. https://doi.org/10.1007/s00432-007-0207-z

Jessie K, Jayapalan JJ, Ong KC, Abdul Rahim ZH, Zain RM, et al. Aberrant proteins in the saliva of patients with oral squamous cell carcinoma. Electrophoresis 2013; 34(17): 2495-502. https://doi.org/10.1002/elps.201300107

Jou YJ, Lin CD, Lai CH, Tang CH, Huang SH, et al. Salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages. Clin Chim Acta 2011; 412(15-16): 1357-65. https://doi.org/10.1016/j.cca.2011.04.004

El-Naggar AK, Mao L, Staerkel G, Coombes MM, Tucker SL, et al. Genetic heterogeneity in saliva from patients with oral squamous carcinomas: implications in molecular diagnosis and screening. J Mol Diagn 2001; 3(4): 164-70. https://doi.org/10.1016/S1525-1578(10)60668-X

Carvalho AL, Henrique R, Jeronimo C, Nayak CS, Reddy AN, et al. Detection of promoter hypermethylation in salivary rinses as a biomarker for head and neck squamous cell carcinoma surveillance. Clin Cancer Res 2011; 17(14): 4782-9. https://doi.org/10.1158/1078-0432.CCR-11-0324

Li Y, St John MA, Zhou X, Kim Y, Sinha U, et al. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res 2004; 10(24): 8442-50. https://doi.org/10.1158/1078-0432.CCR-04-1167

Boyle JO, Mao L, Brennan JA, Koch WM, Eisele DW, et al. Gene mutations in saliva as molecular markers for head and neck squamous cell carcinomas. Am J Surg 1994; 168: 429-32. https://doi.org/10.1016/S0002-9610(05)80092-3

Bernabe DG, Tamae AC, Miyahara GI, Sundefeld ML, Oliveira SP, et al. Increased plasma and salivary cortisol levels in patients with oral cancer and their association with clinical stage. J Clin Pathol 2012; 65(10): 934-9. https://doi.org/10.1136/jclinpath-2012-200695

Sugimoto M, Wong DT, Hirayama A, Soga T and Tomita M. Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancerspecific profiles. Metabolomics 2010; 6(1): 78-95. https://doi.org/10.1007/s11306-009-0178-y

Vajaria BN, Patel KR, Begum R, Shah FD, Patel JB, et al. Evaluation of serum and salivary total sialic acid and alpha-lfucosidase in patients with oral precancerous conditions and oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol 2013; 115(6): 764-71. https://doi.org/10.1016/j.oooo.2013.01.004

Wei J, Xie G, Zhou Z, Shi P, Qiu Y, et al. Salivary metabolite signatures of oral cancer and leukoplakia. Int J Cancer 2011; 129(9): 2207-17. https://doi.org/10.1002/ijc.25881

Radhika T, et al. Salivary Biomarkers in Oral Squamous Cell Carcinoma – An Insight. Journal of Oral Biology and Craniofacial Research 2016; 6(Suppl 1): S51-S54. https://doi.org/10.1016/j.jobcr.2016.07.003

Saxena, Shikha, et al. A Review of Salivary Biomarker: A Tool for Early Oral Cancer Diagnosis. Advanced Biomedical Research 2017; 6: 90. https://doi.org/10.4103/2277-9175.211801

Bano S, David MP and Indira AP. Salivary biomarkers for oral squamous cell carcinoma: An overview. IJSS Case Reports and Reviews 2015; 1(8): 39-45.

Guerra ENS, et al. Diagnostic capability of salivary biomarkers in the assessment of head and neck cancer: A systematic review and meta-analysis. Oral Oncol 2015. https://doi.org/10.1016/j.oraloncology.2015.06.010

Banks RE, Dunn MJ, Hochstrasser DF, Sanchez JC, Blackstock W, et al.

Proteomics: new perspectives, new biomedical opportunities. Lancet 2000; 18: 1749-56.

Li Y, St John MAR, Zhou X, Kim Y, Sinha U, et al. Salivary trans-criptome diagnostics for oral cancer detection. Clin Cancer Res 2004; 10: 8442-50. https://doi.org/10.1158/1078-0432.CCR-04-1167

Li Y, Zhou X, StJohn MAR and Wong DT. RNA Profiling of cellfree saliva using microarray technology. J Dent Res 2004; 83: 199-20. https://doi.org/10.1177/154405910408300303

Fraser CG. Inherent biological variation and reference values. Clin Chem Lab Med 2004; 42(7): 758-64. https://doi.org/10.1515/CCLM.2004.128

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Published

19-11-2017

How to Cite

Kharma, M. Y., Alkhatib, O. ., Alalwani, M. S., Albishi, W., & Alalwi, S. (2017). Importance of Salivary Biomarkers in the Detection of Oral Cancer (Review Article). The Journal of Dentists, 5(2), 59–64. https://doi.org/10.12974/2311-8695.2017.05.02.2

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