Acetylcholinesterase Inhibitory Effect of Some Medicinal Herbs Used in Iranian Traditional Medicine for Memory Improvement
DOI:
https://doi.org/10.12974/2311-858X.2013.01.01.3Keywords:
Acetylcholinesterase inhibitor, Alpinia officinarum, Alzheimer, Iranian Traditional Medicine.Abstract
Iranian Traditional Medicine (ITM) has a long history in treatment of disorders mostly by using medicinal plants. “Nesyan” is one of the common diseases in ITM that could be partly comparable with Alzheimer. Since, acetylcholinesterase inhibitors (AChEIs) are the usual drugs for Alzheimer, therefore, in order to find new AChEIs, the plants used in ITM are good candidates. In the present investigation, AChEI activity of nine species used for “Nesyan” in ITM have been investigated. Aqueous and total extracts of Phyllanthus emblica, Urginea maritima, Corylus avellana, Alpinia officinarum, Matricaria chamomilla, Curcuma longa, Crocus sativus, Melissa officinalis and Brassica nigra have been prepared by using infusion and maceration methods, respectively. The extracts were dried and their AChEI activity were assessed by using Ellman method with acetylthiocholine iodide as substrate and dithiodinitrobenzoic acid as reagent in 96-well plates at 405 nm. The results demonstrated that only total extract of Alpinia officinarum showed 41.3% inhibition at concentration of 300 µg/ml. Other extracts had trace or no AChEI properties. It is concluded that among the examined species used in ITM, Alpinia officinarum acts as anti-Alzheimer through AChE inhibition possibly with other mechanisms. In order to find the mechanisms of other plants more investigations are necessary.
References
Adams M, Gmünder F, Hamburger M. Plants traditionally used in age related brain disorders-a survey of ethnobotanical literature. Ethnopharmacol 2007; 113(3): 363- 81. http://dx.doi.org/10.1016/j.jep.2007.07.016
Vinutha B, Prashanth D, Salma K, Sreeja SL, Pratiti D, Padmaja R, et al. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity. J Ethnopharmacol 2007; 109(2): 359-63. http://dx.doi.org/10.1016/j.jep.2006.06.014
Frank B, Gupta S. A review of antioxidants and Alzheimer's disease. Ann Clin Psychiatry 2005; 17: 269–86. http://dx.doi.org/10.1080/10401230500296428
Selkoe DJ. Defining molecular targets to prevent Alzheimer's disease. Arch Neurol 2005; 62: 192–5. http://dx.doi.org/10.1001/archneur.62.2.192
Bossy-Wetzel E, Schwarzenbacher R, Lipton SA. Molecular pathways to neurodegeneration. Nat Med 2004; 10: S2–S9. http://dx.doi.org/10.1038/nm1067
Shvaloff A, Neuman E, Guez D. Lines of therapeutics research in alzheimer's disease. Psychopharmacol Bull 1996; 32: 343-52.
Wilcock GK. Current approaches to the treatment of alzheimer's disease. Neurodegeneration 1996; 5: 505-9. http://dx.doi.org/10.1006/neur.1996.0070
Karimi Gh, Iranshahi M, Hosseinalizadeh F, Riahi B, Sahebkar A. Screening of acetylcholinesterase inhibitory activity of terpenoid and coumarin derivatives from the genus Ferula. Pharmacologyonline 2010; 1: 566-74.
Grutzendler J, Morris JC. Cholinesterase inhibitors for alzheimer's disease. Drugs 2001; 61: 41-52. http://dx.doi.org/10.2165/00003495-200161010-00005
Watkins PB, Zimmerman HJ, Knapp MJ, Gracon SI, Lewis KW. Hepatotoxic effects of tacrine administration in patients with alzheimer's disease. J Am Med Assoc 1994; 271: 992-8. http://dx.doi.org/10.1001/jama.1994.03510370044030
Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with alzheimer's disease. Neurol 1998; 50: 136-45. http://dx.doi.org/10.1212/WNL.50.1.136
Aghili Khorasani Shirazi MH. Moalejat-e-Aghili. Translated and edited by: Shams Ardakani MR, Rahimi R, Farjadmand F. Tehran: Rahe Kamal 2008.
Ibn Sina. Qanun fi al-Tibb. Translated by: Sharafkandi A. Tehran: Soroush 1988.
Razi MZ. Al-hawi. Translated and edited by: Afsharipoor S. Tehran: The Academy of Medical Sciences, Islamic Republic of Iran 2005.
Tonkaboni SMM. Tuhfat-ul-momineen. Translated and edited by: Rahimi R, Shams Ardakani MR, Farjadmand F. Tehran: Nashr-e-Shahr 2008.
Aghili Khorasani Shirazi MH. Makhzan al-adviyah. Translated and edited by: Shams Ardakani MR, Rahimi R, Farjadmand F. Tehran: Rahe Kamal 2008.
Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase inhibitor activity. Biochem Pharmacol 1961; 7: 88-95. http://dx.doi.org/10.1016/0006-2952(61)90145-9
Mukheijee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 2007; 21: 1142-5. http://dx.doi.org/10.1002/ptr.2224
Shekarchi M, Hajimehdipoor H, Naghibi F, Ara L, Moazzeni Zehan H. Investigating acetylcholinesterase inhibitory effects of some Ferula species. J Med Plants 2013; 12(46): 107-13.
Hajimehdipoor H, Esmaeili S, Shekarchi M, Emrarian T, Naghibi F. Investigation of some biologic activities of Swertia longifolia. RPS 2013; 8(4): 253-9.
Amin Gh. Popular medicinal plants of Iran. Tehran: Tehran University of Medical Sciences and Medical Ethics and History of Medicine Research Center 2005.
Lu W, Jiang LH. Chemical constituents and pharmacological activities of Alpinia officinarum Hance. China Parm 2006; 15(3): 19-21.
Zhang MF, Shen YQ. Pharmacological study on Alpinia officinarum for dispelling internal cold. Shaanxi J Tradit Chin Med 1996; 17(7): 324.
Lee J, Kim KA, Jeong S, Lee S, Park HJ, Kim NJ, et al. Antiinflammatory, anti-nociceptive, and anti-psychiatric effects by the rhizomes of Alpinia officinarum on complete Freund's adjuvant-induced arthritis in rats. J Ethnopharmacol 2009; 126(2): 258-64. http://dx.doi.org/10.1016/j.jep.2009.08.033
Ling Z, Wei QU, Ju-Qin FU, jing-Yu L. A new diarylheptanoid from the rhizomes of Alpinia officinarum. Chinese J Nat Med 2010; 8(4): 0241-3. http://dx.doi.org/10.3724/SP.J.1009.2010.00241
Shen J, Zhang H, Xu B, Pan J. The anti-oxidative constituents of rhizomes of Alpinia officinarum. Tianran Chanwu Yanjiu Yu Kaifa 1998; 10: 33-6.
Shin D, Kinoshita K, Koyama K, Takahashi K. Antiemetic principles of Alpinia officinarum. J Nat Prod 2002; 65: 1315- 8. http://dx.doi.org/10.1021/np020099i
Kang SS, Kim JS, Son KH, Kim HP, Chang HW. Isolation of COX-2 inhibitors from Alpinia officinarum. Korean journal of Pharmacognosy 2000; 31: 57-62.
Kim YU, Son HK, Ahn MJ, Lee SS, Lee SK, Inhibition of 5 - reductase activity by diarylheptanoids from Alpinia officinarum. Planta Med 2003; 69: 72-4. http://dx.doi.org/10.1055/s-2003-37028
Srividya AR, Dhanabal SP, Misra VK, Suja G. Antioxidant and antimicrobial activity of Alpinia officinarum. Indian J Pharm Sci 2010; 72(1): 145-8. http://dx.doi.org/10.4103/0250-474X.62233
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