Paraneoplastic Cerebellar Degeneration Associated with Gynecological Malignancy: Two Contrasting Case Reports 

Authors

  • George Salloum Wright State University Boonshoft School of Medicine, Department of Surgery, Dayton, OH, USA
  • Ronald E. Warwar Wright State University Boonshoft School of Medicine, Department of Surgery, Dayton, OH, USA
  • Jackie Van Dyke Wright State University Boonshoft School of Medicine, Department of Surgery, Dayton, OH, USA
  • David Hemmings Wright State University Boonshoft School of Medicine, Department of Surgery, Dayton, OH, USA

DOI:

https://doi.org/10.12974/2309-6136.2014.02.01.6

Keywords:

Paraneoplastic cerebellar degeneration, diplopia, nystagmus, ovarian cancer, gynecological cancer.

Abstract

Paraneoplastic cerebellar degeneration is a rare neurologic disorder associated with several forms of cancer, including gynecological. It may present months or years prior to or after the diagnosis of cancer. Recognition of the condition is paramount for early diagnosis of the underlying malignancy and/or for mitigating the permanent effects of the cerebellar degeneration. We present two cases of paraneoplastic cerebellar degeneration associated with gynecological malignancies which illustrate the varied timings of presentation and outcomes of the disorder. 

References

Braik T, Evans AT, Telfer M, et al. Paraneoplastic neurological syndromes: unusual presentations of cancer. A practical review. Am J Med Sci 2010;340(4):301-8. http://dx.doi.org/10.1097/MAJ.0b013e3181d9bb3b

Russo AE, Scalone S, Leonardi GC, et al. Paraneoplastic cerebellar degeneration associated with ovarian cancer. Oncol Lett 2013;5(2):681-3.

Tanaka Y, Suzuki N, Takao M, et al. Paraneoplastic cerebellar degeneration with fallopian tube adenocarcinoma. Gynecol Oncol 2005;99(2):500-3. http://dx.doi.org/10.1016/j.ygyno.2005.06.064

Selby KJ, Warner J, Klempner S, et al. Anti-Yo antibody associated with occult fallopian tube carcinoma. Int J Gynecol Pathol 2011;30(6):536-8. http://dx.doi.org/10.1097/PGP.0b013e3182237ca6

Matsushita H, Kodama S, Aoki Y, et al. Paraneoplastic cerebellar degeneration with anti-Purkinje cell antibody associated with primary tubal cancer. Gynecol Obstet Invest 1998;45:140-3. http://dx.doi.org/10.1159/000009942

Suri V, Khan NI, Jadhao N, et al. Paraneoplastic cerebellar degeneration in Hodgkin’s lymphoma. Ann Indian Acad Neurol2012;15(3):205-7. http://dx.doi.org/10.4103/0972-2327.99720

Shimazu Y, Minakawa EN, Nishikori M, et al. A case of follicular lymphoma associated with paraneoplastic cerebellar degeneration. Intern Med 2012;51:1387-92. http://dx.doi.org/10.2169/internalmedicine.51.7019

Key RG, Root JC. Anti-Yo mediated paraneoplastic cerebellar degeneration in the context of breast cancer: a case report and literature review. Psychooncology 2013;22(9):2152-5. http://dx.doi.org/10.1002/pon.3270

Porto L, Miranda M, Gomes A, et al. Paraneoplastic neurological syndrome as an initial indicator of small cell carcinoma of the lung. BMJ Case Rep 2013; Feb 6. http://dx.doi.org/10.1371/journal.pone.0066002

Goldstein BH, Birk CL, Van Houten M, et al. Ovarian cancer and late onset paraneoplastic cerebellar degeneration. Arch Gynecol Obstet 2009; 280: 99–101. http://dx.doi.org/10.1007/s00404-008-0822-1

Greenlee JE. Treatment of paraneoplastic cerebellar degeneration. Curr Treat Options Neurol 2013;15(2):185- 200. http://dx.doi.org/10.1007/s11940-012-0215-4

Eichler TW, Totland C, Haugen M, et al. CDR2L antibodies: A new player in paraneoplastic cerebellar degeneration. PLoS One 2013;8(6):e66002.

Esposito M, Penza P, Orefice G, et al. Successful treatment of paraneoplastic cerebellar degeneration with rituximab. J Neurooncol 2008;86:363-4. http://dx.doi.org/10.1007/s11060-007-9479-z

Shams’ili S, Grefkens J, Leeuw B, et al. Paraneoplastic cerebellar degeneration associated with anti-neuronal antibodies: analysis of 50 patients. Brain 2003;126:1409-18. http://dx.doi.org/10.1093/brain/awg133

Rojas I, Graus F, Keime-Guibert F, et al. Long term clinical outcome of paraneoplastic cerebellar degeneration and anti- Yo antibodies. Neurology 2000;55:713-5. http://dx.doi.org/10.1212/WNL.55.5.713

Downloads

Published

2014-02-05

How to Cite

Salloum, G., Warwar, R. E., Dyke, J. V., & Hemmings, D. (2014). Paraneoplastic Cerebellar Degeneration Associated with Gynecological Malignancy: Two Contrasting Case Reports . Journal of Ocular Diseases and Therapeutics, 2(1), 27–29. https://doi.org/10.12974/2309-6136.2014.02.01.6

Issue

Section

Articles