Chitosan-Coated Gold Nanoparticles as Promising Nanosystem for Directional Drug Delivery to Target Organs
DOI:
https://doi.org/10.12974/2311-8792.2014.02.02.3Keywords:
Chitosan-coated gold nanoparticles, carrier properties, organ distribution and egestion under oral alimentation.Abstract
The present research under the application of a chitosan-coated gold nanoparticles nanosystem was made on experimental animals into the chitosan transportation property of orally administered nanostructured gold delivery into the bloodstream and its further distribution through the animals’ organs. Transportation properties are dependent on the molecular weight of chitosan: in case the molecular weight is equal or more than 30’000 an accumulation of nanoparticles is found in kidney, liver, lung and spleen as opposed to the oligomer of chitosan with the molecular weight of ~ (5-10)* 103 when the nanostructured gold is detected in kidney and liver only. The adaptogenic activity of the chitosan-coated gold nanoparticles nanosystem was revealed in conditions of hypoxia simulation. A significant feature of the nanosystem is that the nanostructured gold is completely egested from an organism within a month.
References
E.G. Dmitrieva, Nanoparticles in Medicine and Pharmaceutics, Collection of scientific articles “Fundamental Sciences and Practice” with the Third International Teleconference “Problems and Prospects of Contemporary Medicine, Biology and Ecology”. 1 (2010) 4.
L. Matthews, R.K. Kanwar, Sh. Zhou, V. Punj, J.R. Kanwar, Applications of Nanomedicine in Antibacterial Medical Therapeutics and Diagnostics, The Open Tropical Medicine Journal. 3 (2010) 1-9;
M.-Ch. Daniel, I. Astruc, Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology, Chem. Rev. 104 (2004) 293-346.
G.S. Terentyuk, I.L. Maksimova, N.I. Dikht, A.G. Terentyuk, et al. Cancer laser therapy using gold nanoparticles // Lasers for Medical Applications. Diagnostics, Therapy and Surgery. A volume in Woodhead Publishing Series in Electronic and Optical Materials (2013) 659-699.
J. Lee, D. K. Chatterjee, M. H. Lee, S. Krishnan. Gold nanoparticles in breast cancer treatment: Promise and potential pitfalls // Cancer Letters. 347 (2014) 46-53.
A.C. Jayalekshmi, Chandra P. Sharma. Gold nanoparticle incorporated polymer/bioactive glass composite for controlled drug delivery application // Colloids and Surfaces B: Biointerfaces, 126 (2015) 280-287.
A.D. Pomogailo, A.S. Rosenberg, I.E. Uflyand, Metal Nanoparticles in Polymers, Chemistry, Moscow, 2000.
P. Renuga Devi, C. Senthil Kumar, P. Selvamani, N. Subramanian, K. Ruckmani. Synthesis and characterization of Arabic gum capped gold nanoparticles for tumortargeted drug delivery // Materials Letters. 139 (2015) 241- 244.
M. Sheikh Mohamed, S. Veeranarayanan, A. Ch. Poulose, Y. Nagaoka, H. Minegishi, Y. Yoshida, T. Maekawa, D. S. Kumar. Type 1 ribotoxin-curcin conjugated biogenic gold nanoparticles for a multimodal therapeutic approach towards brain cancer // Biochimica et Biophysica Acta. 1840 (2014) 1657-1669.
Guodong Zhang, Zhi Yang, Wei Lu, Rui Zhang, Qian Huang, Mei Tian, Li Li, Dong Liang, Chun Li. Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice // Biomaterials. 10 (2009): 1928-1936.
K.G. Skryabina, Chitin and Chitosan: Preparation, Properties and Implementation, Science, Moscow, 2002.
M. Dash, F. Chiellini, R.M. Ottenbrite, E. Chiellini, Chitosan-A versatile semi-synthetic polymer in biomedical applications, Progress in Polymer Science, 36 (2011) 981-1014.
V.P. Varlamov, S.V. Nemtsov, V.E. Tikhonov, Chitosin and Chitosan: Preparation, Properties and Implementation, Russain Chitin Society, 2010.
N.O. Yakimovich, E.A. Jerofeeva, E.A. Alexandrova, E.A. Koryagina, A.V. Malkov, A.S. Koryagin, L.A. Smirnova, Antioxidant Properties of Gold Nanoparticles Under Normal Conditions and the Effect of Ionizing Reactions, Vestnik NNSU, 1 (2006) 60-68.
D. R. Bhumkar, H. M. Joshi, M.Sastry, V. B. Pokharkar, Chitosan Reduced Gold Nanoparticles as Novel Carriers for Transmucosal Delivery of Insulin, Pharmaceutical Research, 8 (2007) 1415-1426.
N.G. Khlebtsov, L.A. Dykman, Biodistribution and Toxicity of Gold Nanoparticles, Russian nanotechnology, 1-2 (2011) 39- 59.
E. Caballero-Díaz, M. Valcárcel. Toxicity of Gold Nanoparticles // Comprehensive Analytical Chemistry. Gold Nanoparticles in Analytical Chemistry. 66 (2014) 207-254.
W. H. De Jong, W. I. Hagens, P. Krystek, M. C. Burger, A. J.A.M. Sips, R. E. Geertsma. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration // Biomaterials, 29 (2008) 1912-1919.
S. Fraga, A. Brandão, M. E. Soares, T. Morais, J. A. Duarte, L. Pereira, L. Soares, C. Neves, E. Pereira, M. de Lourdes Bastos, H. Carmo. Short- and long-term distribution and toxicity of gold nanoparticles in the rat after a single-dose intravenous administration // Nanomedicine: Nanotechnology, Biology and Medicine, 10 (2014) 1757- 1766.
L.A. Smirnova, A.P. Alexandrov, N.O. Yakimovich, N.V. Sapogova, A. V. Kirsanov, L. V. Soustov, N. M. Bityurin, UV induced formation of gold nanoparticles in a poly(methyl methacrylate) matrix, Doklady Akademii Nauk, 6 (2005) 779- 781.
J. F. Hillyer, R. M. Albrecht. Gastrointestinal Persorption and Tissue Distribution of Differently Sized Colloidal Gold Nanoparticles. J. Pharm. Sci., 12 (2001) 1927-1936.
A. Albanse, W.C.W. Chan. Effect of gold nanoparticle aggregation on cell uptake and toxicity // ACS «Nano». 5 (2011) 5478-5489.
Rikkardo A.A. Mutsarelli, Chitosan per os. Translation from English, Vektor:- T&S, Nizhny Novgorod, 2001, p. 372.
Rikkardo A.A. Mutsarelli, Chitosan per os. Translation from English, Vektor-T&S, Nizhny Novgorod, 2001, p. 15.
J.F. Hillyer, R.M. Albrecht, Correlative Instrumental Neutron Activation Analysis, Light Microscopy, Transmission Electron Microscopy, and X-ray Microanalysis for Qualitative and Quantitative Detection of Colloidal Gold Spheres in Biological Specimens. Microsc. Microanal, 5 (1998) 481-490;
W.H. de Jong, W.I. Hagens, P. Krystek, M.C. Burger, A.J. Sips, R.E. Geertsma. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials, 29 (2008) 1912-1919.
