On Demand Degradable h-BN–Fe3O4 Nanocomposite Powders for BNCT Delivery Agents (Focused Mini-Review)

Authors

  • Levan Chkhartishvili "Engineering Physics Department, Doctoral Program in Engineering Physics, Georgian Technical University, Merab Kostava Avenue 77, 0160, Tbilisi, Georgia" & "Semiconducting and Powder Composite Materials Laboratory, Ferdinand Tavadze Metallurgy and Materials Science Institute, Elizbar Mindeli Street 8b, 0186, Tbilisi, Georgia"

DOI:

https://doi.org/10.12974/2311-8717.2023.11.06

Keywords:

Boron nitride, Magnetite, Nanopowder composite, Therapeutic agents controlled delivery, Boron-Neutron-Capture-Therapy

Abstract

This mini-review is focused on the nanopowder composite material h-BN–Fe3O4 (hexagonal boron nitride–magnetite) developed by the author’s research group in recent years. Effective methods of their synthesis, structural and morphological characteristics, and physical properties are briefly described. They show that h-BN–Fe3O4 composite nanoparticles can serve as boron isotope 10B delivery agents in BNCT (Boron-Neutron-Capture-Therapy) having high medical efficacy with controlled delivery, low toxicity and on-demand degradability.

References

Barth RF, Mi P, Yang W. Boron delivery agents for neutron capture therapy of cancer. Cancer Commun 2018; 38: 35 (1-15). https://doi.org/10.1186/s40880-018-0299-7

Ali F, Hosmane NS, Zhu Y. Boron chemistry for medical applications. Molecules 2020; 25: 828 (1-24). https://www.mdpi.com/1420-3049/25/4/828

Li J, Tu Zh, Liu Zh. Development history of boron delivery agents. Scientia Sinica Chimica 2020; 50: 1296-319. – in Chinese. https://doi.org/10.1360/SSC-2020-0114

Makatsaria Sh. Role of BNCT in modern radiation medicine (Mini review). Nano Stud 2020; 20: 111-8. – in Georgian. https://doi.org/10.52340/ns.2020.13

Seneviratne DS, Saifi O, Mackeyev Y, Malouff T, Krishnan S. Next-generation boron drugs and rational translational studies driving the revival of BNCT. Cells 2023; 12: 1398 (1-19). https://doi.org/10.3390/cells12101398

Ciofani G, Raffa V, Menciassi A, Cuschieri A. Folate functionalized boron nitride nanotubes and their selective uptake by glioblastoma multiforme cells: Implications for their use as boron carriers in clinical boron neutron capture therapy. Nanoscale Res Lett 2009; 4: 113-21. https://doi.org/10.1007/s11671-008-9210-9

Niskanen J, Zhang I, Xue Y, Golberg D, Maysinger D, Winnik FM. Dually-functionalized boron nitride nanotubes to target glioblastoma multiforme. Mater Today Chem 2020; 16: 100270 (1-9). https://doi.org/10.1016/j.mtchem.2020.100270

Zhitnyak IYu, Sukhorukova IV, Koval’skiy AM, Matveev AT, Bychkov IN, Shtanskiy DV, Glushankova NA. The study of new anticancer drug delivery system based on the boron nitride nanoparticles. Adv Mol Oncol 2016; 3: 34-41. – in Russian. https://doi.org/10.17650/2313-805X.2016.3.2.34-41

Li L, Li J, Shi Y, Du P, Zhang Z, Liu T, Zhang R, Liu Zh. On-demand biodegradable boron nitride nanoparticles for treating triple negative breast cancer with boron neutron capture therapy. ACS Nano 2019; 13: 13843-52. https://doi.org/10.1021/acsnano.9b04303

Lu F, Wang F, Cao L, Kong ChY, Huang X. Hexagonal boron nitride nanomaterials: Advances towards bioapplications. Nanosci Nanotechnol Lett 2012; 4: 949-61. https://doi.org/10.1166/nnl.2012.1444

Brljak N, Parab AD, Rao R, Slocik JM, Naik RR, Knecht MR, Walsh TR. Material composition and peptide sequence affects biomolecule affinity to and selectivity for h-boron nitride and graphene. Chem Commun 2020; DOI 10.1039/d0cc02635b: 1-4. https://doi.org/10.1039/D0CC02635B

Doan TC, Li J, Lin JY, Jiang HX. Growth and device processing of hexagonal boron nitride epilayers for thermal neutron and deep ultraviolet detectors. AIP Adv 2016; 6: 075213 (1-11). https://doi.org/10.1063/1.4959595

Makatsaria Sh, Chkhartishvili L, Dekanosidze Sh, Chedia R. Nanopowder boron compounds doped with ferromagnetic clusters for BNCT. Int J Adv Nano Comput Anal 2023; 2: 1-12. https://www.researchlakejournals.com/index.php/IJANCA/article/view/189

Hung Ch-Ch, Hurst J, Santiago D, Rogers RB. Exfoliation of Hexagonal Boron Nitride via Ferric Chloride Intercalation (Report NASA/TM – 2014-218125). Cleveland: National Aeronautics and Space Administration Glenn Research Center 2014. https://ntrs.nasa.gov/api/citations/20140005373/downloads/20140005373.pdf

Pis I, Nappini S, Bondino F, Onur Mentes T, Sala A, Locatelli A, et al. Fe intercalation under graphene and hexagonal boron nitride in-plane heterostructure on Pt(111). Carbon 2018; 134: 274-82. https://doi.org/10.1016/j.carbon.2018.03.086

Patel RB, Liu J, Eng J, Iqbal Z. One-step CVD synthesis of a boron nitride nanotube–iron composite. J Mater Res 2011; 26: 1132-9. https://doi.org/10.1557/jmr.2011.66

Molla A, Hussain S. Base free synthesis of iron oxide supported on boron nitride for the construction of highly functionalized pyrans and spirooxindoles. RSC Adv. 2016; 6: 5491-502. https://doi.org/10.1039/C5RA21969H

Zhang C, He Y, Li F, Di H, Zhang L, Zhan Y. h-BN decorated with Fe3O4 nanoparticles through mussel-inspired chemistry of dopamine for reinforcing anticorrosion performance of epoxy coatings. J. Alloys Compd 2016; 685: 743-51. https://doi.org/10.1016/j.jallcom.2016.06.220

Hwang DY, Choi KH, Park JE, Suh DH. Evolution of magnetism by rolling up hexagonal boron nitride nanosheets tailored with superparamagnetic nanoparticles. Phys Chem Chem Phys 2017, 19: 4048-55. https://doi.org/10.1039/C6CP08353F

Da Silva WM, Ribeiro H, Ferreira TH, Ladeira LO, Sousa EMB. Synthesis of boron nitride nanostructures from catalyst of iron compounds via thermal chemical vapor deposition technique. Physica E 2017; 89: 177-82. http://dx.doi.org/10.1016/j.physe.2017.01.030

Konopatsky AS, Firestein KL, Evdokimenko ND, Kustov AL, Baidyshev VS, Chepkasov IV, et al. Microstructure and catalytic properties of Fe3O4/BN, Fe3O4(Pt)/BN, and FePt/BN heterogeneous nanomaterials in CO2 hydrogenation reaction: Experimental and theoretical insights. J Catal 2021; 402: 130-42. https://doi.org/10.1016/J.JCAT.2021.08.026

Bangari RS, Yada VK Singh JK, Sinha N. Fe3O4-functionalized boron nitride nanosheets as novel adsorbents for removal of arsenic(III) from contaminated water. ACS Omega 2020; 5: 10301-14. https://doi.org/10.1021/acsomega.9b04295

Dee G, O’Donoghue O, Rafferty A, Gannon L, McGuinness C, Gun’ko YK. Boron nitride nanosheets functionalized with Fe3O4 and CoFe2O4 magnetic nanoparticles for nanofiltration applications. ACS Appl Nano Mater 2023; 6: 12526-36. https://doi.org/10.1021/acsanm.3c02375

Chkhartishvili L, Rukhadze L, Margiev B, Tsagareishvili O, Darchiashvili M. Carbon and isostructural boron nitride nanomaterials doped with ferromagnetic clusters. In: Hussain ChM, Patankar KK, editors. Fundamentals and Industrial Applications of Magnetic Nanoparticles. Duxford: Elsevier 2022; Ch. 6, pp. 165-233. https://doi.org/10.1016/B978-0-12-822819-7.00012-0

Chkhartishvili L, Mikeladze A, Tsagareishvili O, Kvatchadze V, Tavkhelidze V, Mestvirishvili Z, et al. Advanced boron carbide matrix nanocomposites obtained from liquid-charge: Focused review. Condens Matter 2023; 8: 37 (1-54). https://doi.org/10.3390/condmat8020037

Chkhartishvili L, Chedia R, Tsagareishvili O, Mirzayev M, Makatsaria Sh, Gogolidze N, et al. Preparation of neutron-capturing boron-containing nanosystems. In: Proceedings of the 9th International Conference and Exhibition on Advanced and Nano Materials. Victoria, Canada 24 – 26 October 2022. International Academy of Energy, Minerals and Materials 2022: pp. 1-15. ISBN: 978-1-77835-171-6. https://iaemm.com/Pubdetails.php

Chkhartishvili L, Makatsaria Sh, Gogolidze N. Boron-containing fine-dispersive composites for neutron-therapy and neutron-shielding. In: Proceedings of the International Scientific-Practical Conference “Innovations and Modern Challenges – 2022”. Tbilisi, Georgia 18 – 19 November 2022; Publishing House “Technical University” 2023: pp. 221-6. ISBN 978-9941-28-944-6. https://publishhouse.gtu.ge/en/

Chkhartishvili L, Makatsaria Sh, Gogolidze N, Tsagareishvili O, Batsikadze T, Mirzayev M, et al. Obtaining boron carbide and nitride matrix nanocomposites for neutron-shielding and therapy applications. Condens Matter 2023; 8: 92 (1-27). https://doi.org/10.3390/condmat8040092

Makatsaria Sh, Kekutia Sh, Markhulia J, Mikelashvili V, Chkhartishvili L, Chedia R. Magnetic properties of nanopowder h-BN doped with Fe and Fe3O4 nanoclusters. Nano Stud 2021–2022; 21/22: 287-92. https://doi.org/10.52340/ns.2022.08

Arutinovi D. Actual problems of boron-neutron-capture-therapy and prospects for its implementation in Georgia. Nano Stud 2019; 19: 153-202. https://www.nanostudies.org/index.php/nano/issue/archive

Shanidze G. Dosimetric monitoring of radiation safety of medical personnel in case of Center for Radiation and Nuclear Medicine. Nano Stud 2021–2022; 21/22: 223-66. https://doi.org/10.52340/ns.2022.21

Downloads

Published

2023-12-26

How to Cite

Chkhartishvili, L. . (2023). On Demand Degradable h-BN–Fe3O4 Nanocomposite Powders for BNCT Delivery Agents (Focused Mini-Review). Journal of Composites and Biodegradable Polymers, 11, 41–48. https://doi.org/10.12974/2311-8717.2023.11.06

Issue

Section

Articles