Polymerization Kinetics, Biodegradation and pH-Responsive Behavior of Poly[(Citric Acid-co-PEG-400)-Ran-(Glycerol)]

Authors

  • M. Abdul Matin Department of Materials Science & Engineering, 4th Science Building, University of Rajshahi, Rajshahi-6205, Bangladesh
  • Abu Mahmud Department of Materials Science & Engineering, 4th Science Building, University of Rajshahi, Rajshahi-6205, Bangladesh
  • M. Nurul Islam Department of Medicine, Rajshahi Medical College, Rajshahi-6000, Bangladesh
  • Anjuman Ara Khatun Department of Medicine, Rajshahi Medical College, Rajshahi-6000, Bangladesh
  • Monishita Nuzhat Chowdhury Department of Medicine, Rajshahi Medical College, Rajshahi-6000, Bangladesh

DOI:

https://doi.org/10.12974/2311-8717.2018.06.3

Keywords:

Poly[(citric acid-co-PEG-400)-ran-(glycerol)], Biodegradable polymer, Microbial degradation, Hydrolytic degradation, pH responsive behavior.

Abstract

Poly[(citric acid-co-PEG-400)-ran-(glycerol)] was synthesized in a vacuum reaction vessel in presence of p-toluene sulphonic acid as catalyst. Synthesized co-polyester was characterized by its glass transition temperature (Tg), FTIR spectrum, elemental analysis and equilibrium swelling behaviors in water and in ethanol. Polymerization kinetics of the said copolymer was figured out. Biodegradation nature was monitored following simple soil burial test and microbial degradation study using the bacterium Bacillus subtilis inoculums. Hydrolytic degradation study reveals that the polymer remains almost intact in acid buffer solution of pH 1.2 but was gradually degraded in phosphate buffer solution of pH 7.4 at 37˚C. Because of having such pH responsive behavior, this co-polyester could be an ideal future candidate for the site targeted drug delivery medium. 

References

Isabelle Vroman and Lan Tighzert, Biodegradable Polymers, Materials 2009; 2(2): 307-344. https://doi.org/10.3390/ma2020307

T. Jothy Stella. Determination of Physico-Chemical Properties of Biopolyester Resins from cardanol and castor oil, J. Chem. Pharm. Res. 2016; 8(4): 472-478. https://www.jocpr.com

Krushna kumar J Gandhi, Subhash V Deshmane, Kailash R Biyani. Polymers in Pharmaceutical Drug Delivery System: A Review. Int J Pharm Sci Rev Res 2012; 14(2): 10: 57‐66. https://www.globalresearchonline.net

Jayasekara R, Harding I, Bowater I and Lonergan G. Biodegradability of Selected Range of Polymers and Polymer Blends and Standard Methods for Assessment of Biodegradation. J Polymer Environ 2005; 13: 231. https://doi.org/10.1007/s10924-005-4758-2

Apurva Srivastava, Tejaswita Yadav, Soumya Sharma, Anjali Nayak, Akanksha Kumari, Nidhi Mishra. Polymers in Drug Delivery. Journal of Biosciences and Medicines 2016; 4: 69- 84. https://doi.org/10.4236/jbm.2016.41009

Benny Cherian & Eby Thomas Thachil . Synthesis of Unsaturated Polyester Resin-Effect of Choice of reactants and Their Relative Proportion. Int J of Polymeric Mat and Polymeric Biomat 2004; 10(53): 829-845. https://doi.org/10.1080/00914030490502364

Gilding DK and Reed AM. Biodegradable polymers for use in surgery polyglycolic/poly (lactic acid) homo and copolymers: 1. Polymer 1979; 12(20): 1459-1464. https://doi.org/10.1016/0032-3861(79)90009-0

S. Gogolewvki. Resorbable polymers for internal fixation, Clinical Materials 1992; 1-2(10): 13-20. https://doi.org/10.1016/0267-6605(92)90079-9

Vyas SP and Khar RK. Controlled Drug Delivery: Concepts and Advances. 2nd Ed. Vallabhprakashan, New Delhi, 2012; 156‐189.

Kathryn E. Uhrich, Scott M. Cannizzaro and Robert S. Langer. Polymeric Systems for Controlled Drug Release. Chem. Rev 1999; 99: 3181‐3198. https://doi.org/10.1021/cr940351u

Park JH, Ye ML, and Park K. Biodegradable Polymers for Microencapsulation of Drugs, Molecules 2005; 10: 146-161. https://doi.org/10.3390/10010146

Qiang Wei, Nan-Nan Deng, Junling Guo, and Jie Deng. Synthetic Polymers for Biomedical Applications. Int J Biomater 2018; Article ID 7158621: 2 pages, https://doi.org/10.1155/2018/7158621

Van Savage G. and Rhodes CT. The sustained release coating of solid dosage forms: a historical review, Drug Dev. Industrial Pharm 1995; 21(1): 93. https://doi.org/10.3109/03639049509048098

Longer MA, Ch'ng HS, and Robinson JR. Bioadhesive Polymers as Platforms for Oral Controlled Drug Delivery III: Oral Delivery of Chlorothiazide Using a Bioadhesive Polymer. J Pharm Sci1985; 74(4): 406. https://doi.org/10.1002/jps.2600740408

Acemoglu M. Chemistry of Polymer Biodegradation and Implications on Parenteral Drug Delivery. Int J Pharm 2004; 277: 133. https://doi.org/10.1016/j.ijpharm.2003.06.002

Abu Mahmud, MA. Bakr. Poly(maleic acid-co-propane-1,2- diol-co-adipic acid)for pH-triggered Drug Delivery, J react funct polym 2015; 96: 21-24. https://doi.org/10.1016/j.reactfunctpolym.2015.09.002

RC Rowe, PJ Sheskey, ME Quinn, Handbook of Pharmaceutical Excipients, Sixth Ed., RPS Press, Great Britain, 2009. https://trove.nla.gov.au/version/208133392

Jeffrey M. Halpern, Richard Urbanski, Allison K. Weinstock, David F. Iwig, Robert T. Mathers, and Horst von Recum. A Biodegradable Thermoset Polymer Made by Esterification of Citric Acid and Glycerol, J Biomed Mater Res A 2014; 102(5): 1467-1477. https://doi.org/10.1002/jbm.a.34821

Schou-Pedersen AM, Hansen SH, Moesgaard B, Ø stergaard, J. Kinetics of the Esterification of Active Pharmaceutical Ingredients Containing Carboxylic Acid Functionality in Polyethylene Glycol: Formulation Implications. J Pharm Sci 2014; 103(8): 2424-33. https://doi.org/10.1002/jps.24062

Jerzy Skrzypek, Maria Kulawska, Maria Lachowska, Henryk Moroz, Kinetics of the Synthesis of Butyl Phthalates over Methane Sulfonic Acid Catalyst. Reac Kinet Mech Cat 2010; 100: 301-307. https://doi.org/ 10.1007/s11144-010-0185-z

Yan Li, Xian Si Kong, Zhong Wei Wang, and Qing Yu. Kinetic Study of the Esterification Reaction of Ethylene Glycol with Phenyl Phosphonic Acid and Benzene Phosphinic Acid. Adv Mater Res 2012; 581(1): 228-232. https://www.scientific.net/AMR.581-582.228ÅE

Downloads

Published

2018-05-03

How to Cite

Matin, M. A., Mahmud, A., Islam, M. N., Khatun, A. A., & Chowdhury, M. N. (2018). Polymerization Kinetics, Biodegradation and pH-Responsive Behavior of Poly[(Citric Acid-co-PEG-400)-Ran-(Glycerol)]. Journal of Composites and Biodegradable Polymers, 6, 20–27. https://doi.org/10.12974/2311-8717.2018.06.3

Issue

Section

Articles