Design and Sustained Release Evaluation of Rifampicin from Polyurethane Membranes
DOI:
https://doi.org/10.12974/2311-8717.2013.01.01.5Keywords:
Biological test, drug delivery, in vitro, polyurethane membranes, rifampicin, sustained release.Abstract
Drug delivery membranes based on polyurethanes have been used for prolonged release of rifampicin. Therefore, two polyurethane structures with concentrations in urethane groups of 1.5 mmol/g and 2.5 mmol/g, respectively were tested for delivery of rifampicin. The influence of the surface morphology in drug release was evaluated by scanning electron microscopy (SEM), atomic force microscopy (AFM) and contact angle measurements. The kinetics, drug release mechanisms and dynamic vapour sorption (DVS) were studied. Prolonged nature of the release of rifampicin is assured by the urethane concentration 2.5 mmol/g but also to the surface of the membrane systems. It was found that the rifampicin release is function of polymer-drug membranes composition and the surface properties. One can assume that the mechanism of diffusion is Fickian, and the experimental data verify this law. Finally, the possibility of applications of the polyurethane matrix with rifampicin was shown by biological test.
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