Editorial Cellular Senescence: The p53/Senescence-Messaging Secretome Connection

Authors

  • Paul J. Higgins Center for Cell Biology & Cancer Research Albany Medical College, Albany NY, USA

Abstract

Editorial

References

Campisi J, d'Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8: 729-740. http://dx.doi.org/10.1038/nrm2233

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Coppe JP, Desprez PY, Krtolica A, Campisi J (2001) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annual Rev Path 5: 99-118. http://dx.doi.org/10.1146/annurev-pathol-121808-102144

Mu XC, Higgins PJ (1995) Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts. J Cell Physiol 165: 647-657. http://dx.doi.org/10.1002/jcp.1041650324

Kuilman T, Peeper DS (2009) Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 9: 81-94. http://dx.doi.org/10.1038/nrc2560

Kortlever RM, Higgins PJ, Bernards R (2006) Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 8: 877-884. http://dx.doi.org/10.1038/ncb1448

Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GRS, Mutlu GM, Miyata T, Vaughan DE (2014) PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. PNAS 111: 7090-7095. http://dx.doi.org/10.1073/pnas.1321942111

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51. http://dx.doi.org/10.1038/36285

Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479: 232-236. http://dx.doi.org/10.1038/nature10600

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Published

2014-12-31

How to Cite

Higgins, P. J. (2014). Editorial Cellular Senescence: The p53/Senescence-Messaging Secretome Connection. Journal of Aging and Gerontology, 2(2), 58–59. Retrieved from https://savvysciencepublishers.com/index.php/jag/article/view/735

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