Alpha and Theta EEG Rhythms Activity Reveal Deep Changes in Resting Brain State in Subjects with Prodromal Alzheimer's Disease
DOI:
https://doi.org/10.12974/2309-6128.2014.02.01.3Keywords:
EEG, alpha rhythm, theta rhythm, EEG, MCI, SPECT, resting state.Abstract
The increase of EEG alpha3/alpha2 frequency power ratio has been associated with AD-converters subjects with mild cognitive impairment (MCI) as well as a reduction in the regional cerebral blood flow (rCBF).
In this study, the association between alpha3/alpha2 frequency power ratio with rCBF changes in subjects with MCI was evaluated.
The alpha3/alpha2 frequency power ratio was computed in 27 subjects with MCI. Two groups were obtained according to the median values of alpha3/alpha2, at a cut-off of 1.17. In the groups so obtained, the correlation between brain perfusion and EEG markers were detected.
In the MCI group with the alpha3/alpha2 frequency power ratio above 1,17 as compared to the group with alpha3/alpha2 frequency power ratio below 1.17 there was: 1) a constant trend to lower rCBF values; 2) smaller hippocampal volumes; 3) higher theta frequency power.
The higher EEG alpha3 /alpha2 frequency power ratio individuates two different group of MCI subjects. A complex interplay between alpha and theta rhythms activity MCI patients is suggested in patients with prodromal Alzheimer's disease.
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