Peptide Sharing between Parvovirus B19 and DNA Methylating/ Histone Modifying Enzymes. A Potential Link to Childhood Acute Lymphoblastic Leukemia
DOI:
https://doi.org/10.12974/2311-8687.2017.05.01.4Keywords:
Peptide sharing, immune crossreactivity, DNA methyl transferases, histone methyl (acetyl) ltransferases, aberrant gene expression.Abstract
The present study investigates the hypothesis that the immune responses that follow active infections may crossreact with (and damage) molecules related to DNA methylation and histone modification, in this way determining the aberrant gene expression so often reported in acute lymphoblastic leukemia (ALL). We used Parvovirus B19 - a pathogen that has been repeatedly studied in ALL – as a model and analysed the viral polyprotein for peptide sharing with human proteins involved in gene expression. Data are reported that document an ample peptide sharing between Parvovirus B19 and human DNA/histone methylation and modification enzymes. Remarkably, the shared peptide platform is endowed with a high immunologic potential. This study calls attention on immune cross reactivity as a molecular mechanism that may connect infections to cancer and warns against active immunizations based on entire viral antigens.
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