Recurrent Rhinovirus Detections in Children Following a Rhinovirus-Induced Wheezing Exacerbation: A Retrospective Study 

Authors

  • Sofie Halmø Hürdum School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia and Department of Pulmonary Medicine, Hvidovre Hospital, University of Copenhagen, Kettegård Allé 30, 2650 Hvidovre, Denmark
  • Guicheng Zhang School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia and School of Public Health, Curtin University, GPO Box U1987, Perth, Western Australia, 6845, Australia
  • Siew-Kim Khoo School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia and Telethon Kids Institute, The University of Western Australia, PO Box 855, West Perth, Western Australia, 6872, Australia
  • Joelene Bizzintino School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia and Telethon Kids Institute, The University of Western Australia, PO Box 855, West Perth, Western Australia, 6872, Australia
  • Kimberley Marie Franks School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia and Telethon Kids Institute, The University of Western Australia, PO Box 855, West Perth, Western Australia, 6872, Australia
  • Katie Lindsay Department of Microbiology, Pathwest Laboratory Medicine WA, Princess Margaret Hospital for Children, GPO Box D184, Perth, Western Australia, 6840, Australia
  • Anthony David Keil Department of Microbiology, Pathwest Laboratory Medicine WA, Princess Margaret Hospital for Children, GPO Box D184, Perth, Western Australia, 6840, Australia
  • Desmond William Cox School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia and Our Lady’s Children’s Hospital, Crumlin, Dublin 12 Ireland
  • Jack Goldblatt School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia
  • Yury Alexandrovich Bochkov Department of Pediatrics, University of Wisconsin Clinical Science Center 600 Highland Avenue Madison, Wisconsin, USA
  • James Gern Department of Pediatrics, University of Wisconsin Clinical Science Center 600 Highland Avenue Madison, Wisconsin, USA
  • Charlotte Suppli Ulrik Department of Pulmonary Medicine, Hvidovre Hospital, University of Copenhagen, Kettegård Allé 30, 2650 Hvidovre, Denmark
  • Peter Neils Le Souëf School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia
  • Ingrid Alisa Laing School of Paediatrics and Child Health, The University of Western Australia, GPO Box D184, Perth Western Australia, 6840, Australia and Telethon Kids Institute, The University of Western Australia, PO Box 855, West Perth, Western Australia, 6872, Australia

DOI:

https://doi.org/10.12974/2311-8687.2015.03.01.2

Keywords:

Allergy, asthma, attack, childhood, respiratory virus, wheeze.

Abstract

Introduction: It is unclear if children with a rhinovirus (RV)-induced wheezing exacerbation are more susceptible to viruses longitudinally, and whether a parental history of asthma and/or allergy impacts their susceptibility.

The objective of this study was to determine if RV, RV-A and RV-C related wheezing exacerbations in children were associated with prior or subsequent viral detections and investigate the role of parental history of asthma and allergy.

Materials and methods: Children presenting to hospital with acute wheeze were prospectively recruited and tested for respiratory viruses. Data on viruses detected in other respiratory samples (May 1997 to December 2012) were collected from hospital microbiology records and additional RV testing was performed on stored hospital respiratory samples (September 2009 to December 2012). A positive parental history was defined as either parent with self-reported asthma and/or allergy.

Results: At recruitment, RV was detected in 69.2% of samples from children with an acute wheezing episode (n=373, 0–16 years of age), with RV-C the most common virus (65.5%). Children with a history of parental asthma and/or allergy and RV at recruitment had a 14-fold increased incidence rate ratio (IRR) of subsequent RV detection (IRR 14.0, 95% CI 1.9–104.1; p=0.01) compared with children without RV at recruitment. Children without this parental history had a reduced incident rate ratio for samples assessed during this time (IRR 0.5, 95% CI 0.3–0.9; p=0.03).

Conclusion: Children with a parental history of asthma and/or allergy may become more susceptible to recurrent symptomatic RV infections. 

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Published

2015-03-24

How to Cite

Hürdum S. H., Zhang, G., Khoo, S.-K., Bizzintino, J., Franks, K. M., Lindsay, K., Keil, A. D., Cox, D. W., Goldblatt, J., Bochkov, Y. A., Gern, J., Ulrik, C. S., Souëf, P. N. L., & Laing, I. A. (2015). Recurrent Rhinovirus Detections in Children Following a Rhinovirus-Induced Wheezing Exacerbation: A Retrospective Study . International Journal of Pediatrics and Child Health, 3(1), 10–18. https://doi.org/10.12974/2311-8687.2015.03.01.2

Issue

Vol. 3 No. 1 (2015)

Section

Articles