Central Corneal Thickness in Mentally Challenged (MC) Children
DOI:
https://doi.org/10.12974/2311-8687.2014.02.01.1Keywords:
Mentally challenged, central corneal thickness, pachymetry.Abstract
Purpose: A case-control study to assess central corneal thickness (CCT) values in mentally challenged (MC) children.
Participants and Methods: Children with mental disability were enrolled in the study. Age-matched and healthy control subjects from a similar ethnic background were enrolled in the study. Central corneal thickness was measured by ultrasound pachymetry. Six consecutive measurements were made at the center of the cornea of each eye. Only the right eye of each child in each group was included in the statistical analysis.
Results: Twenty-seven children in the MC group (14 boys and 13 girls) and 34 age-matched and healthy control subjects (23 boys and 11girls) were enrolled in the study. The mean age was 9.74 ± 2.697 years (range 7- 17years). The mean age in control group was 10.2 ± 2.185 years (range, 8-17 years). In the MC group, mean CCT value was 505.76 ± 31.23 mm in the right eye. In the control group, mean CCT value was 528.59 ± 30.35 mm in the right eye. CCT value in the MC group was significantly lesser than in the control group for right eye (P =0.006).
Conclusions: Mentally challenged (MC) children had a decreased central corneal thickness compared with healthy control subjects. CCT should be kept in mind during measurements of intraocular pressure (IOP) in MC children with because decreased central corneal thickness may give an artificially low intraocular pressure measurement by applanation tonometry.
References
van Splunder J, Stilma JS, Bernsen RM, Evenhuis HM. Prevalence of ocular diagnoses found on screening 1539 adults with intellectual disabilities. Ophthalmology 2004; 111: 1457-63. http://dx.doi.org/10.1016/j.ophtha.2003.12.051 DOI: https://doi.org/10.1016/j.ophtha.2003.12.051
McCulloch DL, Sludden PA, McKeown K, Kerr A. Vision care requirements among intellectually disabled adults: a residence-based pilot study. J Intellect Disabil Res 1996; 40: 140-50. http://dx.doi.org/10.1111/j.1365-2788.1996.tb00615.x DOI: https://doi.org/10.1111/j.1365-2788.1996.tb00615.x
Cheng H, Bates AK, Wood L, McPherson K. Positive correlation of corneal thickness and endothelial cell loss: serial measurements after cataract surgery. Arch Ophthalmol 1988; 106: 920-2. http://dx.doi.org/10.1001/archopht.1988.01060140066026 DOI: https://doi.org/10.1001/archopht.1988.01060140066026
Evereklioglu C, Ylmaz K, Bekir NA. Decreased central corneal thickness in children with Down syndrome. J Pediatr Ophthalmol Strabismus 2002; 39: 274-7. DOI: https://doi.org/10.3928/0191-3913-20020901-07
Carr J, Hersh P. Patient evaluation for refractive surgery. In: Azar DT, ed. Refractive Surgery, Stanford, CT: Appleton & Lange Publishers, 1997; 101-9.
Doughty MJ, Zaman ML. Human corneal thickness and its impact on intraocular pressure measures: a review and metaanalysis approach. Surv Ophthalmol 2000; 44: 367-408. http://dx.doi.org/10.1016/S0039-6257(00)00110-7 DOI: https://doi.org/10.1016/S0039-6257(00)00110-7
Ehlers N, Hansen FK. Central corneal thickness in lowtension glaucoma. Acta Ophthalmol (Copenth) 1974; 52: 740-6. http://dx.doi.org/10.1111/j.1755-3768.1974.tb01109.x DOI: https://doi.org/10.1111/j.1755-3768.1974.tb01109.x
Nemesure B, Wu SY, Hennis A, Leske MC. Barbados Eye Study Group. Corneal thickness and intraocular pressure in the Barbados eye studies. Arch Ophthalmol 2003; 121: 240- 244. http://dx.doi.org/10.1001/archopht.121.2.240 DOI: https://doi.org/10.1001/archopht.121.2.240
Hussein M, Paysse E, Bell N, Coats D, Brady McCreery K, Koch D, et al. Corneal thickness in children. Am J Ophthalmol 2004; 138: 744-8. http://dx.doi.org/10.1016/j.ajo.2004.06.030 DOI: https://doi.org/10.1016/j.ajo.2004.06.030
Liu Z, Pflugfelder SC. Corneal thickness is reduced in dry eye. Cornea 1999; 18: 403-407. http://dx.doi.org/10.1097/00003226-199907000-00002 DOI: https://doi.org/10.1097/00003226-199907000-00002
Mandell RB, Fatt I. Thinning in the human cornea on awakening. Nature 1965; 208: 292-293. http://dx.doi.org/10.1038/208292a0 DOI: https://doi.org/10.1038/208292a0
Miglior S, Albe E, Guareschhi M, Mandelli G, Gomarasca S, Orzalesi N. Intraobserver and interobserver reproducibility in the evaluation of ultrasonic pachymetry measurements of central corneal thickness. Br J Ophthalmol 2004; 88: 174-7. http://dx.doi.org/10.1136/bjo.2003.023416 DOI: https://doi.org/10.1136/bjo.2003.023416
Ehlers N. Hansen FK, Aasved H. Biometric correlations of corneal thickness. Acta Ophthalmol Scand 1975; 53: 652- 659. http://dx.doi.org/10.1111/j.1755-3768.1975.tb01784.x DOI: https://doi.org/10.1111/j.1755-3768.1975.tb01784.x
Gordon M, Beiser J, Brandt J, Heuer D, Higginbotham E, Johnson C, et al. The Ocular Hypertension Treatment Study: Baseline factors that predict the onset of primary open angle glaucoma. Arch Ophtalmol 2002; 120: 714-20. http://dx.doi.org/10.1001/archopht.120.6.714 DOI: https://doi.org/10.1001/archopht.120.6.714
Damji KF, Muni RH, Munger RM. Influence of corneal variables on accuracy of intraocular pressure measurement. J Glaucoma 2003; 12: 69-80. http://dx.doi.org/10.1097/00061198-200302000-00015 DOI: https://doi.org/10.1097/00061198-200302000-00015
Freedman SF. Central corneal thickness in children- does it help or hinder our evaluation of eyes at risk for glaucoma. J AAPOS 2008; 12: 1-2. http://dx.doi.org/10.1016/j.jaapos.2007.12.004 DOI: https://doi.org/10.1016/j.jaapos.2007.12.004
Tong L, Saw S, Siak J, Gazzard G, Tan D. Corneal thickness determination and correlates in singaporean school children. Invest Ophthalmol Visual Sciences 2004; 45: 4004-9. http://dx.doi.org/10.1167/iovs.04-0121 DOI: https://doi.org/10.1167/iovs.04-0121
Remzi K, Mesut E, Ramazan Y, Ugur Can K, Feyzi H, Mustafa D. Central corneal thickness in individuals with intellectual disabilities. Cornea 2007; 26: 421-2. http://dx.doi.org/10.1097/ICO.0b013e318030d246 DOI: https://doi.org/10.1097/ICO.0b013e318030d246