Cold Agglutinin Urticaria Secondary to Mycoplasma Pneumoniae Infection in Childhood: A Case Report

Authors

  • Clelia Cusmano University of Messina - Department of Human Pathology of the Adult and Developmental Age “G. Barresi”, AOU Policlinico “G. Martino”
  • Giorgia Ceravolo "University of Messina - Department of Human Pathology of the Adult and Developmental Age “G. Barresi”, AOU Policlinico “G. Martino”" & "Department of Neuromuscular Disorders, Institute of Neurology, University College London (UCL), London, UK"
  • Agata Vitale University of Messina - Department of Human Pathology of the Adult and Developmental Age “G. Barresi”, AOU Policlinico “G. Martino”
  • Giuseppina Zirilli University of Messina - Department of Human Pathology of the Adult and Developmental Age “G. Barresi”, AOU Policlinico “G. Martino”
  • Malgorzata Wasniewska University of Messina - Department of Human Pathology of the Adult and Developmental Age “G. Barresi”, AOU Policlinico “G. Martino”
  • Eloisa Gitto Unit of Neonatal Intensive Care, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy
  • Mariella Valenzise University of Messina - Department of Human Pathology of the Adult and Developmental Age “G. Barresi”, AOU Policlinico “G. Martino”

DOI:

https://doi.org/10.12974/2311-8687.2024.12.10

Keywords:

Cold agglutinin syndrome, Mycoplasma pneumoniae, Childhood, urticaria, Hemolytic anemia

Abstract

This case report discusses a 13-year-old child presenting with bilateral middle-basal pneumonia attributed to Mycoplasma pneumoniae infection. Despite the absence of hemolysis, the patient exhibited symptoms consistent with cold agglutinin syndrome (CAS), including an erythematous-pomfoid urticaria-like rash. Laboratory analyses confirmed CAS with elevated cold agglutinin titers and a recent Mycoplasma pneumoniae infection. Treatment with clarithromycin resolved the pneumonia, and the rash spontaneously regressed. Additionally, hepatic steatosis was detected, likely associated with the patient's overweight status. This case highlights the importance of considering CAS in children with atypical symptoms following Mycoplasma pneumoniae infection.

References

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Published

2024-06-14

How to Cite

Cusmano, C. ., Ceravolo, G. ., Vitale, A. ., Zirilli, G. ., Wasniewska, M. ., Gitto, E. ., & Valenzise, M. . (2024). Cold Agglutinin Urticaria Secondary to Mycoplasma Pneumoniae Infection in Childhood: A Case Report. International Journal of Pediatrics and Child Health, 12, 76–79. https://doi.org/10.12974/2311-8687.2024.12.10

Issue

Vol. 12 (2024)

Section

Articles