Changes in Sputum Microbiocenosis and Clinical Pattern Under Different Vaccination Protocols for Pneumococcal Infection in Patients with Bronchial Asthma

Authors

  • A.D. Protasov Samara State Medical University, 443099, Samara region, Samara, 89 Chapaevskaya str
  • M.P. Kostinov Mechnikov Moscow Research Institute for Vaccines and Sera, 105064, Moscow, 5a Maly Kazenny Lane
  • A.V. Zhestkov Samara State Medical University, 443099, Samara region, Samara, 89 Chapaevskaya str.
  • D.O. Gorbachev Samara State Medical University, 443099, Samara region, Samara, 89 Chapaevskaya str.
  • A.M. Kostinov Lomonosov Moscow State University 119991, Russian Federation, Moscow, 1 Leninskiye Gory
  • M.E. Elner Samara State Medical University, 443099, Samara region, Samara, 89 Chapaevskaya str.
  • T.A. Kozina Samara State Medical University, 443099, Samara region, Samara, 89 Chapaevskaya str.

DOI:

https://doi.org/10.12974/2312-5470.2022.08.05

Keywords:

Bronchial asthma, Pneumococcal vaccination, PCV13, PPV23, Microbiological Examination of Sputum

Abstract

Bronchial asthma is a serious public health issue. It is important to reduce the frequency of attacks for BA patients. Vaccination for pneumococcal infection is an important complementary tool that can improve the clinical pattern of bronchial asthma. The study involved 102 patients with bronchial asthma, who were monitored over 4 years. The patients were divided into 4 groups based on the vaccination scheme used for pneumococcal infection: PCV13, PPV23, PPV23/PCV13, PCV13/PPV23. Sequential vaccination with pneumococcal conjugate and polysaccharide vaccines leads to a decrease in the isolation of pneumococcus from sputum in BA patients, which has a pronounced positive effect on the clinical pattern of this disease, namely, it leads to a decrease in the frequency of attacks, the requirement for courses of antibacterial chemotherapy and hospitalizations, and therefore this vaccination protocol should be included in the standards of BA patient management.

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Published

2022-12-28

How to Cite

Protasov, A. ., Kostinov, M. ., Zhestkov, A. ., Gorbachev, D. ., Kostinov, A. ., Elner, M. ., & Kozina, T. . (2022). Changes in Sputum Microbiocenosis and Clinical Pattern Under Different Vaccination Protocols for Pneumococcal Infection in Patients with Bronchial Asthma. Global Journal of Respiratory Care, 8, 18–27. https://doi.org/10.12974/2312-5470.2022.08.05

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