Changes in Sputum Microbiocenosis and Clinical Pattern Under Different Vaccination Protocols for Pneumococcal Infection in Patients with Bronchial Asthma
DOI:
https://doi.org/10.12974/2312-5470.2022.08.05Keywords:
Bronchial asthma, Pneumococcal vaccination, PCV13, PPV23, Microbiological Examination of SputumAbstract
Bronchial asthma is a serious public health issue. It is important to reduce the frequency of attacks for BA patients. Vaccination for pneumococcal infection is an important complementary tool that can improve the clinical pattern of bronchial asthma. The study involved 102 patients with bronchial asthma, who were monitored over 4 years. The patients were divided into 4 groups based on the vaccination scheme used for pneumococcal infection: PCV13, PPV23, PPV23/PCV13, PCV13/PPV23. Sequential vaccination with pneumococcal conjugate and polysaccharide vaccines leads to a decrease in the isolation of pneumococcus from sputum in BA patients, which has a pronounced positive effect on the clinical pattern of this disease, namely, it leads to a decrease in the frequency of attacks, the requirement for courses of antibacterial chemotherapy and hospitalizations, and therefore this vaccination protocol should be included in the standards of BA patient management.
References
Chuchalin A.G., Avdeev S.N., Aisanov Z.R., Arkhipov V.V., Belevsky A.S., Nenasheva N.M. Approved recommendations on the use of the long-acting anticholinergic drug tiotropium in the treatment of bronchial asthma. Pulmonology. 2015; 25(2): 143-150. https://doi.org/10.18093/0869-0189-2015-25-2-143-150
Protasov A.D. Vaccination against pneumococcal infection in patients with chronic bronchopulmonary pathology (literature review). Bulletin of Modern Clinical Medicine. 2013; 6(2): 6065. https://doi.org/10.20969/VSKM.2013.6(2).60-65
Protasov A.D. Comparative evaluation of the effectiveness of vaccination against pneumococcal infection in patients with bronchial asthma using 13-valent conjugate and 23-valent polysaccharide vaccines. Pulmonology. 2014; 5: 52-56.
Edris, A. Pharmacogenetics of inhaled corticosteroids and exacerbation risk in adults with asthma / A. Edris, E. W. de Roos, M. J. McGeachie // Clin. Exp. Allergy. - 2022; 52(1): 33-45. https://doi.org/10.1111/cea.13829
Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2022. Available from: www.ginasthma.org.
Lukachev I.V., Kostinov M.P., Shabalina S.V., Magarshak O.O., Zhirova S.N. "PNEUMO-23" vaccine in the complex treatment of children with bronchial asthma. Epidemiology and preventive vaccination. 2004; 3(16): 41-44.
Pelton S.I., Weycker D., Farkouh R.A., Strutton D.R., Shea K.M., Edelsber J. Risk of Pneumococcal Disease in Children With Chronic Medical Conditions in the Era of Pneumococcal Conjugate Vaccine. Clinical Infectious Diseases. 2014; 59(5): 615-623. https://doi.org/10.1093/cid/ciu348
Patel, G. B. Comorbidities associated with severe asthma / G. B. Patel, A. T. Peters // J. Precis. Respir. Med. 2019; 2(1): 5-9. https://doi.org/10.2500/jprm.2019.190006
Kostinov MP, Protasov AD, Zhestkov AV, Yastrebova NE, Kostinov AM, Vlasenko AE, Polyshyuk VB, Kostinova AM, Korovkina ES, Ryzhov AA, Shmitko AD. A Randomized Safety Study of 13-Valent Pneumococcal Conjugated Vaccine and Post-Vaccination Immune Response to Streptococcus pneumoniae Serotypes in Adult Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease. Annals of the Russian Academy of Medical Sciences. 2021; 76(3): 324-334. https://doi.org/10.15690/vramn1342
Vaccination and emergency immunoprophylaxis of infectious diseases in pregnant and lactating women: a guide for doctors / under. ed. M.P. Kostinova, L.V. Adamyan, A.P. Cherdantseva, N.A. Ozeretskovsky (ed. 1st). - M.: Group MDV, 2022. 98 p.
Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2018. Available from: www.ginasthma.org.
WHO updates Essential Medicines List with new advice on use of antibiotics, and adds medicines for hepatitis C, HIV, tuberculosis and cancer. 2017. Available at: http://www.who.int/mediacentre/news/releases/2017/essentia l-medicines-list/en /
Dobrikh V.A., Mun I.E., Kovaleva O.A., Digor A.A., Uvarova I.V., Makarevich A.M. Diagnostic significance of cytological examination of effusion of the lower respiratory tract. Far Eastern Medical Journal. 2013; 1: 125-129.
Palange P., Simonds A.K. ERS Handbook of Respiratory Medicine. 2nd ed. UK: Hermes; 2013. https://doi.org/10.1183/9781849840415-hba02
Hof H., Dorries R. Medizinische Mikrobiologie. 2009. https://doi.org/10.1055/b-001-2124
Krechikova O.I. Isolation, identification and determination of antibiotic sensitivity of Streptococcus pneumoniae. Clinical microbiology and antimicrobial chemotherapy. 2000; 2(1): 88-98.
Ford M. Medical Microbiology / M. Ford // Medical Microbiology. - Oxford University Press. - 2010. - P. 365.
Bogdanovich T.M. Isolation, identification and determination of sensitiv ity to antibiotics of Haemophilus influenza. Clinical microbiology and antimicrobial chemotherapy. 2000; 2(2): 93-109.
Lang TA., Sesik M. How to describe statistics in medicine. A guide for authors, editors and reviewers. M.: Practical Medicine; 2011.
