Epithelial Mesenchymal Transformation 

Authors

  • Tugba Karadeniz Department of Pathology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
  • Hatice Yilmaz SifaUniversity Faculty of Medicine, Internal Medicine, 35100 Bornova, Izmir, Turkey
  • Muammer Karadeniz SifaUniversity Faculty of Medicine, Department of Endocrinology, 35100 Bornova, Izmir, Turkey

DOI:

https://doi.org/10.12974/2309-6160.2014.02.01.4

Keywords:

Epithelial-mesenchymal transition, carsinogenesis, metastases

Abstract

The epithelial-mesenchymal transition (EMT) defined as a process by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties to transform into mesenchymal cells. Some signaling events activated transcription factors (Wnt, TGF-b, and FGF family members) that mediate EMT. EMTBeginning of metastasis needs invasion, which is allowed by EMT. Carcinoma cells in primary tumor lose intercellular adhesion mediated by E-cadherin repression and break through the basement membrane with increased invasive properties, and enter the bloodstream through intravasation. After then, when these circulating tumor cells (CTCs) exit the bloodstream to form micrometastases, they undergo its reverse process for clonal outgrowth at these metastatic sites.

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Published

2014-02-05

How to Cite

Karadeniz, T., Yilmaz, H., & Karadeniz, M. (2014). Epithelial Mesenchymal Transformation . Global Journal of Oncologists, 2(1), 22–24. https://doi.org/10.12974/2309-6160.2014.02.01.4

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