Evaluation of Congenital and Chromosomal Anomalies Mortality in Turkey by Joinpoint Regression Analysis
DOI:
https://doi.org/10.12974/2313-0946.2021.06.01.4Keywords:
Joinpoint Regression Analysis, Chromosomal anomalies, Congenital anomaliesAbstract
Congenital anomalies (CAs) represents one of the main cause of fetal death, infant mortality and morbidity, and long-term disability. This study aims that it was to analyze the mortality trends of Congenital and Chromosomal Anomalies (CCAs) mortality in Turkey. This population-based observational study covers nine years in Turkey. CCAs mortality data was reported from the Turkish Statistical Institute death database by gender and age. Age-standardized mortality rates per 100,000 population were calculated by direct standardization using the WHO Reference Population. Average annual percent change (AAPC), annual percent change (APC), and 95% confidence interval (CI) were computed using the joinpoint regression analysis. Joinpoint Regression analysis results showed a significant trend for overall CCA-type mortality over the entire observation period (AAPC=3.9%, 95% CI:1.4 to 6.4). A significant increase in the mortality rate of nervous system (in male: APC:7.6%, 95% CI: 2.2 to 13.4; in female: APC:6.6%, 95% CI:2.6 to 10.7) and circulatory system (in male: APC:4.6%, 95% CI:1.5 to 7.8; in female: APC:3.4%, 95% CI:0.8 to 6.1) were observed in both gender during the study period (p<0.001). Congenital anomalies in Turkey are a major cause of fetal and neonatal death, however, most of the anomalies can be preventable or treatable.
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